Effect of diphenylhydantoin on synaptosome sodium-potassium-ATPase

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Effect of diphenylhydantoin on synaptosome sodium-potassium-ATPase.

Previous studies have demonstrated that electrically induced seizures in rat result in an increased brain intracellular sodium which can be decreased by treatment with sodium diphenylhydantoin (DPH). The correlation of cation transport with membrane-oriented sodium-potassium-adenosine triphosphatase (Na-K-ATPase) prompted an investigation of the effect of DPH upon ATPase enzyme activity.Rat cer...

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ژورنال

عنوان ژورنال: Journal of Clinical Investigation

سال: 1968

ISSN: 0021-9738

DOI: 10.1172/jci105956